Ethyl 2-(3-methoxyphenyl)-4-quinazolinepropionate → N,N-diethyl-2-(3-methoxyphenyl)-4-quinazolinepropanamide

HRID 2232537

反応式

HRID 2232537 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2[N:18]=[C:17]([CH2:19][CH2:20][C:21](OCC)=[O:22])[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=2)[CH:6]=[CH:7][CH:8]=1>C(NCC)C>[CH2:9]([N:10]([CH2:11][CH3:12])[C:21](=[O:22])[CH2:20][CH2:19][C:17]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=[C:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=2)[N:18]=1)[CH3:5]

参加物

3

反応物 1

HCID 13769245Ethyl 2-(3-methoxyphenyl)-4-quinazolinepropionate

生成物 1

HCID 13769156N,N-diethyl-2-(3-methoxyphenyl)-4-quinazolinepropanamide収率 55.5%

試薬・触媒・溶媒 1

HCID 8021Diethylamine溶媒

実験手順

The procedure is as in Example 1, starting with ethyl 2-(3-methoxyphenyl)-4-quinazolinepropionate (1.2 g) and diethylamine (30 cc). After chromatography on silica gel with a cyclohexane/ethyl acetate (1:1 by volume) mixture as eluant, and crystallization in isopropyl ether, N,N-diethyl-2-(3-methoxyphenyl)-4-quinazolinepropanamide (0.36 g), m.p. 87° C., is obtained.

後処理

  1. customAfter chromatography on silica gel with a cyclohexane/ethyl acetate (1:1 by volume) mixture as eluant, and crystallization in isopropyl ether

出典と根拠

ORDレコード
ord-899babe8936a487ba126e7d4fda9b679
出典データセット
uspto-grants-1988_11
特許番号
US04788204

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