Dimethylformamide → Benzoyl chloride, 2,3-dichloro-4,5-difluoro-

HRID 2232645ノート

反応式

HRID 2232645 の反応式
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4](O)=[O:5].CN(C)C=O.S(Cl)([Cl:21])=O>>[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4]([Cl:21])=[O:5]

参加物

4

反応物 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 139380362,3-Dichloro-4,5-difluorobenzoic acid

生成物 1

HCID 10999320Benzoyl chloride, 2,3-dichloro-4,5-difluoro-

実験手順

A solution of 2,3-dichloro-4,5-difluorobenzoic acid (9.3 g) and dimethylformamide (0.013 ml) in thionyl chloride (40 ml) was refluxed for 2.5 hours, and then concentrated. The resulting residue was purified by distillation in nitrogen atmosphere to give the title compound (8.7 g) as pale yellow oil, bp 123°-126° C./40 mmHg.

後処理

  1. concentrationconcentrated
  2. distillationThe resulting residue was purified by distillation in nitrogen atmosphere

出典と根拠

ORDレコード
ord-ea06f8b905af4ef39127de398d3ba8e4
出典データセット
uspto-grants-1988_11
特許番号
US04788320

反応ノート

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