Sodium Hydroxide → (E)-5,5-bis(3-chlorophenyl)-2,4-pentadienoic acid

HRID 2232758ノート

反応式

HRID 2232758 の反応式
C([O:3][C:4](=[O:23])/[CH:5]=[CH:6]/[CH:7]=[C:8]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[CH:17]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[CH:10]=1)C.[OH-].[Na+]>CO>[Cl:15][C:11]1[CH:10]=[C:9]([C:8]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[CH:17]=2)=[CH:7]/[CH:6]=[CH:5]/[C:4]([OH:23])=[O:3])[CH:14]=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 14347255(E)-5,5-bis(3-chlorophenyl)-2,4-pentadienoic acid ethyl ester

生成物 1

HCID 14347243(E)-5,5-bis(3-chlorophenyl)-2,4-pentadienoic acid収率 92.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

(E)-5,5-bis(3-chlorophenyl)-2,4-pentadienoic acid ethyl ester (10.5 g) in methanol (30 mL) was treated with 2N sodium hydroxide solution (20 mL) and the mixture was heated at reflux for 15 minutes. The crude solid, obtained from the usual work up, was crystallized from dichloromethane-hexane to furnish 8.95 g of (E)-5,5-bis(3-chlorophenyl)-2,4-pentadienoic acid, mp 167°-68° C. Recrystallization from ether-hexane gave the analytical specimen, mp 167°-168° C.

後処理

  1. temperaturethe mixture was heated
  2. temperatureat reflux for 15 minutes
  3. customThe crude solid, obtained from the usual work up,
  4. customwas crystallized from dichloromethane-hexane

出典と根拠

ORDレコード
ord-c849ba63e3424a2b923b088f1398cdf3
出典データセット
uspto-grants-1988_11
特許番号
US04788206

反応ノート

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