(E)-5,5-bis(4-chlorophenyl)-2,4-pentadienoic acid ethyl ester → (E)-5,5-bis(4-chlorophenyl)-2,4-pentadienoic acid

HRID 2232760ノート

反応式

HRID 2232760 の反応式
C([O:3][C:4](=[O:23])/[CH:5]=[CH:6]/[CH:7]=[C:8]([C:16]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=1)[C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=1)C>CO.[OH-].[Na+]>[Cl:15][C:12]1[CH:11]=[CH:10][C:9]([C:8]([C:16]2[CH:17]=[CH:18][C:19]([Cl:22])=[CH:20][CH:21]=2)=[CH:7]/[CH:6]=[CH:5]/[C:4]([OH:23])=[O:3])=[CH:14][CH:13]=1

参加物

4

反応物 1

HCID 14347256(E)-5,5-bis(4-chlorophenyl)-2,4-pentadienoic acid ethyl ester

生成物 1

HCID 14347245(E)-5,5-bis(4-chlorophenyl)-2,4-pentadienoic acid収率 95%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

A mixture of (E)-5,5-bis(4-chlorophenyl)-2,4-pentadienoic acid ethyl ester (7.5 g) in methanol (30 mL) and 2N sodium hydroxide solution (15 mL) was heated at reflux for 30 minutes. The crude solid obtained from the usual work up, was crystallized from ether-hexane to yield 6.55 g of (E)-5,5-bis(4-chlorophenyl)-2,4-pentadienoic acid, mp 213°-215° C. Recrystallization of a portion from 2-propanol furnished the analytical sample, mp 214°-215° C.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 30 minutes
  3. customThe crude solid obtained from the usual work up,
  4. customwas crystallized from ether-hexane

出典と根拠

ORDレコード
ord-9fe4fb2b06c94f23bf0f328aac46bcb6
出典データセット
uspto-grants-1988_11
特許番号
US04788206

反応ノート

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