Sodium Hydroxide → (E)-5,5-bis(3-nitrophenyl)-2,4-pentadienoic acid

HRID 2232763ノート

反応式

HRID 2232763 の反応式
C([O:3][C:4](=[O:27])/[CH:5]=[CH:6]/[CH:7]=[C:8]([C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([N+:24]([O-:26])=[O:25])[CH:19]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-:17])=[O:16])[CH:10]=1)C.[OH-].[Na+]>O>[N+:15]([C:11]1[CH:10]=[C:9]([C:8]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([N+:24]([O-:26])=[O:25])[CH:19]=2)=[CH:7]/[CH:6]=[CH:5]/[C:4]([OH:27])=[O:3])[CH:14]=[CH:13][CH:12]=1)([O-:17])=[O:16]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 14347249(E)-5,5-bis(3-nitrophenyl)-2,4-pentadienoic acid ethyl ester

生成物 1

HCID 14347259(E)-5,5-bis(3-nitrophenyl)-2,4-pentadienoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of (E)-5,5-bis(3-nitrophenyl)-2,4-pentadienoic acid ethyl ester (6.1 g) methanol (25 mL) and 2N sodium hydroxide solution (12.5 mL) was stirred at reflux for 15 minutes, then was diluted with water (50 mL) and concentrated in vacuo to remove the methanol. The basic solution was poured into a mixture of ice and 2N hydrochloric acid (20 mL), and the resulting buff-colored solids were filtered and dried to afford 5,5g of (E)-5,5-bis(3-nitrophenyl)-2,4-pentadienoic acid mp 234°-237° C. Recrystallization of a portion from chloroform-ethanol furnished the acid as its 0.25 molar hydrate, mp 237°-238° C.

後処理

  1. temperatureat reflux for 15 minutes
  2. concentrationconcentrated in vacuo
  3. customto remove the methanol
  4. additionThe basic solution was poured into a mixture of ice and 2N hydrochloric acid (20 mL)
  5. filtrationthe resulting buff-colored solids were filtered
  6. customdried

出典と根拠

ORDレコード
ord-76eb824d6ac74c39a51310a8a2023512
出典データセット
uspto-grants-1988_11
特許番号
US04788206

反応ノート

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