N-bromobutanimide → 3-Bromo-2-(4-fluorophenyl)imidazo[1,2-a]pyrazine

HRID 2233077ノート

反応式

HRID 2233077 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[N:14][CH:13]=[CH:12][N:11]3[CH:16]=2)=[CH:4][CH:3]=1.[Br:17]N1C(=O)CCC1=O>C(Cl)Cl>[Br:17][C:16]1[N:11]2[CH:12]=[CH:13][N:14]=[CH:15][C:10]2=[N:9][C:8]=1[C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 32311372-(4-Fluorophenyl)imidazo[1,2-a]pyrazine

生成物 1

HCID 498448783-Bromo-2-(4-fluorophenyl)imidazo[1,2-a]pyrazine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 2-(4-fluorophenyl)imidazo[1,2-a]pyrazine (Preparation #2, 0.176 g, 0.783 mmol) in DCM (3 mL) was added N-bromosuccinimide (0.153 g, 0.862 mmol) dropwise. After about 20 minutes, the mixture was concentrated under reduced pressure and purified by flash silica gel chromatography using EtOAc as the eluent to yield the title compound (0.130 g, 54%>: LC/MS (Table 1, Method a) Rt=2.0 min; MS m/z: 294.2 (M+H)+.

後処理

  1. concentrationthe mixture was concentrated under reduced pressure
  2. custompurified by flash silica gel chromatography

出典と根拠

ORDレコード
ord-53fd89d613044b3ea6bca610ac9040f4
出典データセット
uspto-grants-2010_05
特許番号
US07709468B2

反応ノート

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