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1-(3-Chloropropyl)-4-phenylpiperidine → 7-methoxy-4-(1-methylethyl)-6-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(3-Chloropropyl)-4-phenylpiperidine | HCID 203689 | — |
| 反応物 | Fumarate | HCID 5460307 | — |
| 反応物 | HCID 19927654 | HCID 19927654 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 溶媒 | tert-Butyl methyl ether | HCID 15413 | — |
| 生成物 | 7-methoxy-4-(1-methylethyl)-6-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one | HCID 19927638 | 85% |
反応手順
Method D (2.5 h at 85° C.); starting materials: 6-hydroxy-7-methoxy-4-(1-methylethyl)-2H-1-benzopyran-2-one (example 105) and 1-(3-chloropropyl)-4-phenyl-piperidine; yield 85%; fusion point 62°-65° C. (from TBME). Fumarate: method E; yield 65%; fusion point 155°-157° C. (from acetone, boiled out with TBME).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05428038 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-13dfe9d867b84ecfb63a521715149af8 |
| 出典メモ | uspto-grants-1995_06 |