Ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate → (2-Bromo-4-methylthiazol-5-yl)methanol
反応式
[BH4-].[Na+].C([O:5][C:6]([C:8]1[S:12][C:11]([Br:13])=[N:10][C:9]=1[CH3:14])=O)C>C(O)C.O>[Br:13][C:11]1[S:12][C:8]([CH2:6][OH:5])=[C:9]([CH3:14])[N:10]=1参加物
5
実験手順
sodium borohydride (1.2 g, 31.2 mmol) is carefully added to a solution of 2-Bromo-4-methyl-thiazole-5-carboxylic acid ethyl ester (3.6 g, 15.6 mmol) in ethanol (100 mL) and water (1 mL) and stirred at room temperature for twelve hours. The solvent is carefully removed under reduced pressure, the residue is taken up in ethylacetate and washed with water. The organic phase is separated and dried over MgSO4. The organic solvent is removed under reduced pressure to give 3.2 g of (2-Bromo-4-methyl-thiazol-5-yl)-methanol, which was used without further purification.
後処理
- customThe solvent is carefully removed under reduced pressure
- washwashed with water
- customThe organic phase is separated
- dry with materialdried over MgSO4
- customThe organic solvent is removed under reduced pressure
出典と根拠
- ORDレコード
- ord-0126dbe6ec424ef7b6a4942e2ba2dd08
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07709481B2
反応ノート
読み込み中…