Hydrochloric Acid → HCID 59295961、化合物

HRID 2233397ノート

反応式

HRID 2233397 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[C:5]2[C:13]([O:15]C)=[O:14].[OH-].[Na+].Cl>CO>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][CH:6]=[C:5]2[C:13]([OH:15])=[O:14]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 53429435Methyl 6-fluoro-1-oxo-1,2-dihydroisoquinoline-4-carboxylate

生成物 1

HCID 59295961HCID 59295961、化合物収率 95.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
80 °C

実験手順

To a solution of methyl 6-fluoro-1-oxo-1,2-dihydroisoquinoline-4-carboxylate (1.3 g) in methanol (3 ml) was added a aqueous solution (3 ml) of sodium hydroxide (1 g) and the reaction mixture was heated at 80° C. for 3 h. The reaction was cooled to 20° C. and carefully acidified with concentrated hydrochloric acid. The white precipitate was isolated by filtration, washed with water and methanol to yield the title compound (1.16 g)

後処理

  1. temperatureThe reaction was cooled to 20° C.
  2. customThe white precipitate was isolated by filtration
  3. washwashed with water and methanol

出典と根拠

ORDレコード
ord-0868ada0a3724d0eac7566f608a05aaf
出典データセット
uspto-grants-2010_05
特許番号
US07709500B2

反応ノート

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