化工社化工社 化学情報印刷レポート · 研究参考用
Salicylic acid, hydrazide → ortho-(5-Methyl-1,3,4-oxadiazol-2-yl)-phenol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Salicylic acid, hydrazide | HCID 13637 | — |
| 反応物 | Triethyl orthoacetate | HCID 66221 | — |
| 溶媒 | 1-Propanol | HCID 1031 | — |
| 生成物 | ortho-(5-Methyl-1,3,4-oxadiazol-2-yl)-phenol | HCID 135979760 | 44.5% |
反応手順
90 g (0.6 mole) of salicylic acid hydrazide and 388.8 g (2.4 moles) of triethyl orthoacetate in 500 ml of n-propanol are refluxed for 84 hours. When the mixture has cooled, the precipitate is filtered off and recrystallized from a mixture of toluene and petroleum ether. 47 g of colorless crystals (26.7% of theory) are obtained; melting point 74°-76° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04353904 |
| 出典データセット | uspto-grants-1982_10 |
| ORD ID | ord-eab5ff6792184edcb3686bb496315b85 |
| 出典メモ | uspto-grants-1982_10 |