Sodium Iodide → 2-(4-Methoxyphenyl)-4-iodomethyl-5-methyloxazole

HRID 2233556

反応式

HRID 2233556 の反応式
[I-:1].[Na+].Cl[CH2:4][C:5]1[N:6]=[C:7]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)[O:8][C:9]=1[CH3:10]>CC(C)=O>[I:1][CH2:4][C:5]1[N:6]=[C:7]([C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)[O:8][C:9]=1[CH3:10]

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 144799554-(Chloromethyl)-2-(4-methoxyphenyl)-5-methyl-1,3-oxazole

生成物 1

HCID 224936592-(4-Methoxyphenyl)-4-iodomethyl-5-methyloxazole

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Together with 37.7 g of sodium iodide, 19.9 g of 4-chloromethyl-2-(4-methoxy-phenyl)-5-methyl-oxazole are, in 300 ml of acetone, heated at the boil under reflux for 2 hours. After cooling of the reaction mixture, the solvent was removed under reduced pressure and the residue dissolved in 300 ml of methyl tert-butyl ether, the mixture is washed three times with saturated Na2S2O3 solution and dried over MgSO4, and the solvent is then removed under reduced pressure. This gives 49.8 g of 4-Iodomethyl-2-(4-methoxyphenyl)-5-methyloxazole as a light-brown solid.

後処理

  1. temperatureheated at the boil
  2. temperatureunder reflux for 2 hours
  3. temperatureAfter cooling of the reaction mixture
  4. customthe solvent was removed under reduced pressure
  5. dissolutionthe residue dissolved in 300 ml of methyl tert-butyl ether
  6. washthe mixture is washed three times with saturated Na2S2O3 solution
  7. dry with materialdried over MgSO4
  8. customthe solvent is then removed under reduced pressure

出典と根拠

ORDレコード
ord-e918121f953b4191933a6f57c3dc45fc
出典データセット
uspto-grants-2010_05
特許番号
US07709509B2

関連ノート

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