ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Thiazole → 2-Chloro-4-[4-(tetrahydro-pyran-2-yloxymethyl)-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-benzonitrile

HRID 2233590
ノート
印刷プレビュー

反応式

HRID 2233590 の反応式
Cl[CH2:2][C:3]1[S:7][C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)=[N:5][C:4]=1[CH2:18][O:19][CH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][O:21]1.S1C=CN=C1.C(=O)([O-])[O-].[Cs+].[Cs+].[Cl:37][C:38]1[CH:45]=[C:44]([OH:46])[CH:43]=[CH:42][C:39]=1[C:40]#[N:41]>CN(C)C=O.C(OC(=O)C)C>[Cl:37][C:38]1[CH:45]=[C:44]([O:46][CH2:2][C:3]2[S:7][C:6]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:16])([F:17])[F:15])=[CH:10][CH:9]=3)=[N:5][C:4]=2[CH2:18][O:19][CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][O:21]2)[CH:43]=[CH:42][C:39]=1[C:40]#[N:41]
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 9256ThiazoleHCID 10796Cesium carbonateHCID 5927972-Chloro-4-hydroxybenzonitrileHCID 211094595-(chloromethyl)-4-[(tetrahydro-2H-pyran-2-yloxy)methyl]-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

生成物 1

HCID 592961302-Chloro-4-[4-(tetrahydro-pyran-2-yloxymethyl)-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-benzonitrile収率 105.2%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

3.0 g 5-(Chloromethyl)-4-[(tetrahydro-2H-pyran-2-yloxy)methyl]-2-[4-(trifluormethyl)phenyl]-1,3-thiazole (synthesis is described in WO2002/067912) thiazole were dissolved in 100 ml dimethylformamide. 5.0 g of cesium carbonate and 1.53 g 2-Chloro-4-hydroxybenzonitrile were added and the mixture was stirred at room temperature overnight. Then 300 ml of ethylacetate were added, the mixture washed three times with saturated NaHCO3 solution and brine then dried over MgSO4. The solvent was removed in vacuo to obtain 4.1 g of crude 2-Chloro-4-[4-(tetrahydro-pyran-2-yloxymethyl)-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-benzonitrile as yellow oil. This material was used without further purification.

後処理

  1. washthe mixture washed three times with saturated NaHCO3 solution and brine
  2. dry with materialthen dried over MgSO4
  3. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-3500fc2fa63d4dfa9978e28ac6cdb6d1
出典データセット
uspto-grants-2010_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07709509B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート