関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-(4-Chlorophenoxy)acetone | HCID 239874 | — |
| 反応物 | (2-Bromo-5-nitrophenyl)hydrazine | HCID 53402499 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 7-Bromo-3-(4-chlorophenoxy)-2-methyl-4-nitro-1H-indole | HCID 68617744 | — |
反応手順
A mixture of the compound from (i) (2.4 g) and 1-(4-Chloro-phenoxy)-propan-2-one (1.65 g) in MeCN (20 ml) and water (5 ml) was stirred for 16 h. The volatiles were removed in vacuo. AcOH (50 ml) was added and the reaction heated at 75° C. for 72 h. The volatiles were evaporated under reduced pressure and the residue was purified by chromatography on silica eluting with 5% ethylacetate/iso-hexane. Yield 0.34 g
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07709521B2 |
|---|
| 出典データセット | uspto-grants-2010_05 |
|---|
| ORD ID | ord-bd892b9f6f3440b48b6590ad1fbadcc5 |
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| 出典メモ | uspto-grants-2010_05 |
|---|
