反应详情

温度

75 °C

A mixture of the compound from (i) (2.4 g) and 1-(4-Chloro-phenoxy)-propan-2-one (1.65 g) in MeCN (20 ml) and water (5 ml) was stirred for 16 h. The volatiles were removed in vacuo. AcOH (50 ml) was added and the reaction heated at 75° C. for 72 h. The volatiles were evaporated under reduced pressure and the residue was purified by chromatography on silica eluting with 5% ethylacetate/iso-hexane. Yield 0.34 g

1. customThe volatiles were removed in vacuo
2. additionAcOH (50 ml) was added
3. customThe volatiles were evaporated under reduced pressure
4. customthe residue was purified by chromatography on silica eluting with 5% ethylacetate/iso-hexane