Triethylamine → 4-Amino-3-(4-chlorophenoxy)-2-methyl-1H-indole-1-acetic acid, 1,1-dimethylethyl ester

HRID 2233743ノート

反応式

HRID 2233743 の反応式
[CH3:1][C:2]([O:5][C:6](=[O:30])[CH2:7][N:8]1[C:16]2[C:11](=[C:12]([N+:18]([O-])=O)[CH:13]=[CH:14][C:15]=2Br)[C:10]([O:21][C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=2)=[C:9]1[CH3:29])([CH3:4])[CH3:3].C(N(CC)CC)C>CCOC(C)=O.[Pt]>[NH2:18][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[C:11]=1[C:10]([O:21][C:22]1[CH:23]=[CH:24][C:25]([Cl:28])=[CH:26][CH:27]=1)=[C:9]([CH3:29])[N:8]2[CH2:7][C:6]([O:5][C:2]([CH3:3])([CH3:4])[CH3:1])=[O:30]

参加物

5

反応物 2

HCID 8471TriethylamineHCID 686169457-Bromo-3-(4-chlorophenoxy)-2-methyl-4-nitro-1H-indole-1-acetic acid 1,1 dimethylethyl ester

生成物 1

HCID 866092304-Amino-3-(4-chlorophenoxy)-2-methyl-1H-indole-1-acetic acid, 1,1-dimethylethyl ester

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of the product from step (iii) (0.18 g) in EtOAc (30 ml) was added triethylamine (0.15 ml) and 5% Pt/C (36 mg) and the reaction stirred under hydrogen (1 atm) for 2 h. The reaction was filtered through celite and the filtrate evaporated under reduced pressure. Yield 0.139 g.

後処理

  1. filtrationThe reaction was filtered through celite
  2. customthe filtrate evaporated under reduced pressure

出典と根拠

ORDレコード
ord-ed29568ca60e40dab39b8b97d8cce620
出典データセット
uspto-grants-2010_05
特許番号
US07709521B2

反応ノート

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