trimethylsilyldiazomethane Et2O → 3-Cyano-5-ethyl-1H-pyrrole-2-carboxylic acid methyl ester
反応式
[C:1]([C:3]1[CH:7]=[C:6]([CH2:8][CH3:9])[NH:5][C:4]=1[C:10]([OH:12])=[O:11])#[N:2].[CH3:13][Si](C=[N+]=[N-])(C)C.CCOCC>C1COCC1>[CH3:13][O:11][C:10]([C:4]1[NH:5][C:6]([CH2:8][CH3:9])=[CH:7][C:3]=1[C:1]#[N:2])=[O:12]参加物
4
実験手順
3-Cyano-5-ethyl-1H-pyrrole-2-carboxylic acid (Intermediate 31) (500 mg) was dissolved in anhydrous THF (5 ml) and cooled to 0° C. (Trimethylsilyl)diazomethane/ether (2 ml) was added. The mixture was stirred at room temperature under nitrogen gas for 1 h. The solvent was removed in vacuo and MeOH was added. The mixture was stirred for a further 15 min, the solvent was removed in vacuo and the solid was dried under vacuum to give the title compound (580 mg).
後処理
- additionwas added
- customThe solvent was removed in vacuo and MeOH
- additionwas added
- stirringThe mixture was stirred for a further 15 min
- customthe solvent was removed in vacuo
- customthe solid was dried under vacuum
出典と根拠
- ORDレコード
- ord-a5d960cc378b41489494d9ce2201c888
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07709503B2
反応ノート
読み込み中…