Sodium Carbonate → HCID 11514618、化合物

反応式

FC(F)(F)C([O-])=O.[Cl:8][C:9]1[C:13]([Cl:14])=[C:12]([CH3:15])[NH:11][C:10]=1[C:16]([NH:18][CH:19]1[CH2:24][CH2:23][NH2+:22][CH2:21][CH2:20]1)=[O:17].C(Cl)(Cl)Cl.C(O)(C)C.C([O-])([O-])=O.[Na+].[Na+]>O>[Cl:8][C:9]1[C:13]([Cl:14])=[C:12]([CH3:15])[NH:11][C:10]=1[C:16]([NH:18][CH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)=[O:17]

参加物

実験手順

4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidinium trifluoroacetate (Intermediate 86, 6.07 g) was suspended in water (100 ml). To this was added 100 ml of CHCl3:isopropanol (3:1) and sat. Na2CO3 (50 ml). The organic portion was separated and the aqueous portion was washed with 100 ml portions of CHCl3:isopropanol (3:1) five times. The organic portions were combined, dried with MgSO4 and concentrated to a yellow solid (2.73 g, 64%).