Thionyl Chloride → 3,4-Dichloro-5-cyano-1H-pyrrole-2-carbonyl chloride
反応式
[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([C:8]#[N:9])[NH:4][C:3]=1[C:10]([OH:12])=O.S(Cl)([Cl:15])=O>>[Cl:1][C:2]1[C:6]([Cl:7])=[C:5]([C:8]#[N:9])[NH:4][C:3]=1[C:10]([Cl:15])=[O:12]参加物
3
実験手順
3,4-Dichloro-5-cyano-1H-pyrrole-2-carboxylic acid (Intermediate 131, 0.9 g, 0.2 mmol) was dissolved in excess thionyl chloride (5 ml) and heated to reflux for 30 minutes. The reaction mixture was concentrated and the residue was dissolved in THF and concentrated (×2). The solid (0.82 g, 89%) was pumped to dryness and stored under argon.
後処理
- temperatureheated
- temperatureto reflux for 30 minutes
- concentrationThe reaction mixture was concentrated
- dissolutionthe residue was dissolved in THF
- concentrationconcentrated (×2)
出典と根拠
- ORDレコード
- ord-e58e1c29b64a4b82be79289751a23322
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07709503B2
反応ノート
読み込み中…