Ethyl Acetate → N-(2,2-Diethoxyethyl)-5-phenethyloxy-pentan-1-amine

HRID 2234179ノート

反応式

HRID 2234179 の反応式
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[CH2:16]([O:18][CH:19]([O:22][CH2:23][CH3:24])[CH2:20][NH2:21])[CH3:17].C(N(C(C)C)CC)(C)C.C(OCC)(=O)C>C(O)C>[CH2:16]([O:18][CH:19]([O:22][CH2:23][CH3:24])[CH2:20][NH:21][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH3:17]

参加物

6

反応物 4

HCID 8857Ethyl AcetateHCID 695242,2-DiethoxyethylamineHCID 81531DiisopropylethylamineHCID 197980262-(5-Bromopentoxy)ethylbenzene

生成物 1

HCID 68701993N-(2,2-Diethoxyethyl)-5-phenethyloxy-pentan-1-amine収率 11.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
78 °C

実験手順

2-(5-Bromopentoxy)ethylbenzene (1.5 g) was dissolved in ethanol (30 mL) and treated with 2,2-diethoxyethylamine (0.86 g) and diisopropylethylamine (1.8 mL) at room temperature. The reaction was stirred at 78° C. for 48 hours and was then poured into ethyl acetate (10 mL), washed with water (10 mL) and brine (10 mL). The organic layer was dried over anhydrous magnesium sulphate, filtered and concentrated in vacuo to give the sub-titled compound (0.2 g) as an oil.

後処理

  1. washwashed with water (10 mL) and brine (10 mL)
  2. dry with materialThe organic layer was dried over anhydrous magnesium sulphate
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-51f5bc0719ef414f8a7f7a946f96090f
出典データセット
uspto-grants-2010_05
特許番号
US07709511B2

反応ノート

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