Benzyl Alcohol → Benzyl 2-bromopropanoate

HRID 223420

反応式

HRID 223420 の反応式
[Br:1][CH:2]([CH3:6])[C:3](Cl)=[O:4].[CH2:7]([OH:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.O>C(OCC)C>[Br:1][CH:2]([CH3:6])[C:3]([O:14][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:4]

参加物

5

反応物 3

HCID 244Benzyl AlcoholHCID 962WaterHCID 979802-Bromopropanoyl chloride

生成物 1

HCID 298874Benzyl 2-bromopropanoate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

2-Bromopropionyl chloride (213.4 g) was added dropwise to benzyl alcohol (145.8 g) with stirring under a stream of nitrogen, keeping the temperature of the reaction mixture below 30° C. by cooling with cold water. When all the acid chloride has been added, the mixture was stirred for another two hours at ambient temperature. The reaction mixture was then diluted with diethyl ether (200 ml) and washed with water until free of acid. The ethereal solution was dried and evaporated and the residue distilled to give benzyl 2-bromopropionate, b.p. 82°-85°/0.5 Torr.

後処理

  1. customthe temperature of the reaction mixture below 30° C.
  2. stirringthe mixture was stirred for another two hours at ambient temperature
  3. washwashed with water until free of acid
  4. customThe ethereal solution was dried
  5. customevaporated
  6. distillationthe residue distilled

出典と根拠

ORDレコード
ord-1c00f06cea1740ed92e24c97ab00991d
出典データセット
uspto-grants-1982_10
特許番号
US04354034

関連ノート

読み込み中…