関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | (R)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine | HCID 24739908 | — |
| 反応物 | HCID 178418922 | HCID 178418922 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | (+-)-Duloxetine | HCID 122252 | 84.4% |
反応手順
tBuOK (16.8 g) is added to a solution of (R)-N,N-dimethyl-3-(naphthyloxy)-3-(2-thienyl)propylamine (31 g) in DMSO (100 ml), bubbled with a moderate stream of nitrogen, and the mixture is stirred and heated at 110° C. for 2 hours. After cooling down to lab temperature, the mixture is diluted with water (300 ml) and the racemic product is extracted with toluene. After evaporation, 25 g (84%) of (RS)-N-methyl-3-(naphthyloxy)-3-(2-thienyl)propylamine is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07709662B2 |
|---|
| 出典データセット | uspto-grants-2010_05 |
|---|
| ORD ID | ord-b7337c332b4c441e833ec95572d2cdcd |
|---|
| 出典メモ | uspto-grants-2010_05 |
|---|
