Acetone → HCID 178481590、化合物

HRID 223425ノート

反応式

HRID 223425 の反応式
[CH3:1][C:2]([C:5]1[O:9][N:8]=[C:7]([N:10]2[CH:14]([OH:15])[CH:13]([OH:16])[N:12]([CH3:17])[C:11]2=[O:18])[CH:6]=1)([CH3:4])[CH3:3].CC(C)=O>Cl(O)(=O)(=O)=O.O>[CH2-:2][C:5]([CH3:6])=[O:9].[CH3:4][C:2]([C:5]1[O:9][N:8]=[C:7]([N:10]2[CH:14]([OH:15])[CH:13]([OH:16])[N:12]([CH3:17])[C:11]2=[O:18])[CH:6]=1)([CH3:1])[CH3:3]

参加物

5

反応物 2

HCID 180AcetoneHCID 12918841HCID 12918841、化合物

生成物 1

HCID 178481590HCID 178481590、化合物

試薬・触媒・溶媒 2

HCID 24247Perchloric Acid触媒HCID 962Water溶媒

実験手順

To a solution of 1.0 gram of 3-[5-(1,1-dimethylethyl)-3-isoxazolyl]-4,5-dihydroxy-1-methyl-2-imidazolidinone in 20 ml. of anhydrous acetone were added three drops of 70% perchloric acid. The reaction mixture stood at ambient temperature for sixteen hours, and then was diluted with 100 ml. of water. The white crystalline precipitate was collected by filtration and recrystallized from diethyl ether and hexane to afford 3-[5-(1,1-dimethylethyl)-3-isoxazolyl]4,5-dihydroxy-1-methyl-2-imidazolidinone acetonide. M.P. 157°-159° C. Mass Spectrum M+Theory 295; Found 295.

後処理

  1. waitThe reaction mixture stood at ambient temperature for sixteen hours
  2. additionwas diluted with 100 ml
  3. filtrationThe white crystalline precipitate was collected by filtration
  4. customrecrystallized from diethyl ether and hexane

出典と根拠

ORDレコード
ord-2b8986e1e1d94d508231d76940c60c38
出典データセット
uspto-grants-1982_10
特許番号
US04354030

反応ノート

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