Isopropylamine → 3-(Isopropylamino)-N-methylpropanamide

N-Methylacrylamide (851 mg, 10.00 mmol) and isopropylamine (1.71 mL, 1.18 g, 20.00 mmol) in MeOH (10 mL) were irradiated to 140° C. for 30 mins in a microwave reaction vessel. The reaction mixture was cooled and loaded onto a SCX-2 column and washed with MeOH (100 mL). The crude product was then eluted from the SCX-2 column with NH3 (100 mL, 7M in MeOH) and the volatiles removed under reduced pressure to afford the title compound (1.56 g, Quant.) as an oil, which was used without further purification.

1. temperatureThe reaction mixture was cooled
2. washwashed with MeOH (100 mL)
3. washThe crude product was then eluted from the SCX-2 column with NH3 (100 mL, 7M in MeOH)
4. customthe volatiles removed under reduced pressure

ORDレコード

ord-ce21c49885d04195b9b23c29f45735d7

出典データセット

uspto-grants-2010_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07709471B2