N-(3-dimethylamino-2,2-dimethyl-propyl)-3-methoxy-4-nitro-benzamide → 4-amino-N-(3-dimethylamino-2,2-dimethyl-propyl)-3-methoxy-benzamide

HRID 2234354ノート

反応式

HRID 2234354 の反応式
[CH3:1][N:2]([CH3:22])[CH2:3][C:4]([CH3:21])([CH3:20])[CH2:5][NH:6][C:7](=[O:19])[C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[C:10]([O:17][CH3:18])[CH:9]=1>CCO.[Pd]>[NH2:14][C:11]1[CH:12]=[CH:13][C:8]([C:7]([NH:6][CH2:5][C:4]([CH3:20])([CH3:21])[CH2:3][N:2]([CH3:1])[CH3:22])=[O:19])=[CH:9][C:10]=1[O:17][CH3:18]

参加物

4

反応物 1

HCID 68685548N-(3-dimethylamino-2,2-dimethyl-propyl)-3-methoxy-4-nitro-benzamide2 回

生成物 1

HCID 592951104-amino-N-(3-dimethylamino-2,2-dimethyl-propyl)-3-methoxy-benzamide収率 104.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

反応条件

温度
40 °C

実験手順

A suspension of N-(3-dimethylamino-2,2-dimethyl-propyl)-3-methoxy-4-nitro-benzamide (Intermediate 23; 5.7 g, 18.40 mmol), 5% Pd on charcoal (569 mg) in EtOH (300 mL) was stirred at 40° C. under a hydrogen atmosphere for 16 h. The reaction mixture was then filtered through celite, washed with copious MeOH and the volatiles removed under reduced pressure to afford the title compound (5.36 g, Quant.) as a foam.

後処理

  1. filtrationThe reaction mixture was then filtered through celite
  2. washwashed with copious MeOH
  3. customthe volatiles removed under reduced pressure

出典と根拠

ORDレコード
ord-c80c79f728ad48729456c07f8c630038
出典データセット
uspto-grants-2010_05
特許番号
US07709471B2

反応ノート

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