関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methylacrylamide | HCID 14471 | — |
| 反応物 | (3,5-Dimethoxyphenyl)methanamine | HCID 420973 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-[(3,5-dimethoxyphenyl)methylamino]-N-methyl-propanamide | HCID 61860673 | — |
反応手順
N-methylacrylamide (ABCR; 500 mg, 5.87 mmol) and 3,5-dimethoxybenzylamine (Aldrich; 0.98 mL, 6.46 mmol) were dissolved in ethanol (4 mL) and heated in a microwave at 140° C. for 45 minutes. The mixture was poured onto a 20 g SCX-2 column, washed with methanol and eluted with 3.5N NH3 in methanol. The product fractions were evaporated to the title compound as a yellow oil (1.3 g, 88%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07709471B2 |
|---|
| 出典データセット | uspto-grants-2010_05 |
|---|
| ORD ID | ord-1c1ae45c65f64fcd8a1df57615ec9650 |
|---|
| 出典メモ | uspto-grants-2010_05 |
|---|
