2-Chloro-5-methoxy-4-nitrobenzoic acid → 4-Amino-2-chloro-5-methoxybenzoic acid
反応式
[Cl:1][C:2]1[CH:10]=[C:9]([N+:11]([O-])=O)[C:8]([O:14][CH3:15])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]>CCO.[Pt]>[NH2:11][C:9]1[C:8]([O:14][CH3:15])=[CH:7][C:3]([C:4]([OH:6])=[O:5])=[C:2]([Cl:1])[CH:10]=1参加物
4
実験手順
2-chloro-5-methoxy-4-nitro-benzoic acid (Intermediate 218; 762 mg, 3.8 mmol) was dissolved in EtOH (20 mL) and a catalytic amount of 5% Pt on carbon added under an inert atmosphere. The solution was de-gassed and stirred under an atmosphere of hydrogen at room temperature overnight. The catalyst was filtered off and washed with EtOH and solvent evaporated and the resultant material dried under vacuum to yield the title compound as an off-white solid. (617 mg, 98%)
後処理
- customThe solution was de-gassed
- filtrationThe catalyst was filtered off
- washwashed with EtOH and solvent
- customevaporated
- dry with materialthe resultant material dried under vacuum
出典と根拠
- ORDレコード
- ord-bbe11f1fb4624526a73f895cef25d6b9
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07709471B2
反応ノート
読み込み中…