Ethylene Glycol → 1-(p-Chlorophenyl)cyclobutanecarboxylic acid

HRID 223465

反応式

HRID 223465 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:12]#N)[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[OH-:14].[K+].C(O)C[OH:18]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:12]([OH:18])=[O:14])[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 174Ethylene GlycolHCID 14797Potassium HydroxideHCID 986211-(4-Chlorophenyl)cyclobutanecarbonitrile

生成物 1

HCID 6027611-(p-Chlorophenyl)cyclobutanecarboxylic acid収率 82%

実験手順

1-(4-chlorophenyl)cyclobutane nitrile (5 g) was mixed with ethylene glycol (60 ml) and 40% w/w aqueous potassium hydroxide solution (80 ml) and refluxed under argon for 18 hours. The mixture was cooled, added to ice water and extracted with diethyl ether. The aqueous layer was acidified and the precipitate was filtered off, washed with water, dried and recrystallised from petroleum ether (b.p. 40°-60°) to give the acid as white needles mp 88°-9°, yield 4.5 g (82%). Analysis:

後処理

  1. temperaturerefluxed under argon for 18 hours
  2. temperatureThe mixture was cooled
  3. extractionextracted with diethyl ether
  4. filtrationthe precipitate was filtered off
  5. washwashed with water
  6. customdried
  7. customrecrystallised from petroleum ether (b.p. 40°-60°)

出典と根拠

ORDレコード
ord-0b15928b451447f491f2cfcd17f25208
出典データセット
uspto-grants-1982_10
特許番号
US04355042

関連ノート

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