Trifluoroacetic acid → HCID 57731620、化合物

HRID 2234701ノート

反応式

HRID 2234701 の反応式
C(OC([NH:8][C:9]1[CH:17]=[CH:16][C:15]([C:18]2[CH:19]=[C:20]3[C:26]([C:27]4[CH:28]=[CH:29][CH:30]=[C:31]5[C:35]=4[NH:34][CH:33]=[CH:32]5)=[CH:25][NH:24][C:21]3=[N:22][CH:23]=2)=[CH:14][C:10]=1[C:11]([OH:13])=[O:12])=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH2:8][C:9]1[CH:17]=[CH:16][C:15]([C:18]2[CH:19]=[C:20]3[C:26]([C:27]4[CH:28]=[CH:29][CH:30]=[C:31]5[C:35]=4[NH:34][CH:33]=[CH:32]5)=[CH:25][NH:24][C:21]3=[N:22][CH:23]=2)=[CH:14][C:10]=1[C:11]([OH:13])=[O:12]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 68694688HCID 68694688、化合物

生成物 1

HCID 57731620HCID 57731620、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 2-tert-Butoxycarbonylamino-5-[3-(1H-indol-7-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-benzoic acid (308 mg, 0.66 mmol) in dichloromethane (9 mL) was added trifluoroacetic acid. The resulting solution was stirred for 2 hours at room temperature. The solution was concentrated to give the crude 2-amino-5-[3-(1H-indol-7-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-benzoic acid which was used in next step without further purification. MS: m/z 369 (M+H+).

後処理

  1. concentrationThe solution was concentrated

出典と根拠

ORDレコード
ord-e5f76d4646ff4eef93d174caf9f7f88e
出典データセット
uspto-grants-2010_05
特許番号
US07709645B2

反応ノート

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