(1-Phenyl-cyclohexyl)-carbamic acid benzyl ester → 1-Phenylcyclohexylamine

HRID 2235199ノート

反応式

HRID 2235199 の反応式
C(OC(=O)[NH:10][C:11]1([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)C1C=CC=CC=1>CO.[Pd]>[C:17]1([C:11]2([NH2:10])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

4

反応物 1

HCID 59299316(1-Phenyl-cyclohexyl)-carbamic acid benzyl ester

生成物 1

HCID 318621-Phenylcyclohexylamine収率 90.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Dissolve (1-phenyl-cyclohexyl)-carbamic acid benzyl ester (Preparation 27) (2.87 g, 9.26 mmol) in MeOH (100 mL). Exchange air with nitrogen for three times and then add Pd—C (0.5 g, 10%). Exchange the nitrogen with H2 for three times. Stir the reaction mixture under H2 for over night then remove the Pd—C by filtration. Remove the solvent under reduced pressure to give 1.468 g (90%) of the crude title compound as a colorless oil.

後処理

  1. customthen remove the Pd—C
  2. filtrationby filtration
  3. customRemove the solvent under reduced pressure

出典と根拠

ORDレコード
ord-658ad1920c5349a7aedaee767557cf7c
出典データセット
uspto-grants-2010_05
特許番号
US07713979B2

反応ノート

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