Sodium borohydride → (2,6-Dichloro-3-methoxyphenyl)methanol

HRID 2235210

反応式

HRID 2235210 の反応式
[Cl:1][C:2]1[C:9]([O:10][CH3:11])=[CH:8][CH:7]=[C:6]([Cl:12])[C:3]=1[CH:4]=[O:5].[BH4-].[Na+]>C(O)C>[Cl:1][C:2]1[C:9]([O:10][CH3:11])=[CH:8][CH:7]=[C:6]([Cl:12])[C:3]=1[CH2:4][OH:5]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 149271732,6-Dichloro-3-methoxybenzaldehyde

生成物 1

HCID 21980844(2,6-Dichloro-3-methoxyphenyl)methanol収率 93.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Dissolve 2,6-dichloro-3-methoxy-benzaldehyde (10 g, 48.8 mmol) in ethanol (330 ml) add sodiumborohydride (1.8 g, 48.8 mmol) and stir at room temperature over night. Partition reaction mixture between water and ethyl acetate separate layers wash organic with brine, dry over sodium sulfate, filter and concentrate to yield 9.43 g (93%) of (2,6-Dichloro-3-methoxy-phenyl)-methanol.

後処理

  1. customPartition
  2. customreaction mixture between water and ethyl acetate
  3. customseparate layers
  4. washwash organic with brine
  5. dry with materialdry over sodium sulfate
  6. filtrationfilter
  7. concentrationconcentrate

出典と根拠

ORDレコード
ord-5126c216c3c74222ac698c14d245ede7
出典データセット
uspto-grants-2010_05
特許番号
US07713979B2

関連ノート

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