Tetrahydrofuran → N-(3,3-Dimethyl-6-nitro-2-oxo-1-pent-2-ynyl-2,3-dihydro-1H-indol-5-yl)-3-phenyl-propionamide

HRID 2235402ノート

反応式

HRID 2235402 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[N:7]([CH2:14][C:15]#[C:16][CH2:17][CH3:18])[C:6](=[O:19])[C:5]2([CH3:21])[CH3:20].[CH2:22]1[CH2:26][O:25][CH2:24][CH2:23]1>>[CH3:21][C:5]1([CH3:20])[C:4]2[C:8](=[CH:9][C:10]([N+:11]([O-:13])=[O:12])=[C:2]([NH:1][C:24](=[O:25])[CH2:23][CH2:22][C:26]3[CH:4]=[CH:3][CH:2]=[CH:10][CH:9]=3)[CH:3]=2)[N:7]([CH2:14][C:15]#[C:16][CH2:17][CH3:18])[C:6]1=[O:19]

参加物

3

反応物 2

HCID 8028TetrahydrofuranHCID 593009855-Amino-3,3-dimethyl-6-nitro-1-(pent-2-ynyl)-1,3-dihydro-indol-2-one

生成物 1

HCID 67427209N-(3,3-Dimethyl-6-nitro-2-oxo-1-pent-2-ynyl-2,3-dihydro-1H-indol-5-yl)-3-phenyl-propionamide

実験手順

N-(3,3-Dimethyl-6-nitro-2-oxo-1-pent-2-ynyl-2,3-dihydro-1H-indol-5-yl)-3-phenyl-propionamide is prepared as described in Example 25a starting from A7 (73 mg) using THF (3 ml) as solvent. The crude material (106 mg) is used without further purification.

後処理

  1. customThe crude material (106 mg) is used without further purification

出典と根拠

ORDレコード
ord-41c4b5ce1c1147e7941f9fdc4c58253e
出典データセット
uspto-grants-2010_05
特許番号
US07714010B2

反応ノート

読み込み中…