5-Isopropylamino-3,3-dimethyl-6-nitro-1-pentyl-1,3-dihydro-indol-2-one → 6-Amino-5-isopropylamino-3,3-dimethyl-1-pentyl-1,3-dihydro-indol-2-one

HRID 2235459ノート

反応式

HRID 2235459 の反応式
[CH:1]([NH:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[N+:14]([O-])=O)[N:10]([CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[C:9](=[O:22])[C:8]2([CH3:24])[CH3:23])([CH3:3])[CH3:2]>CN(C)C=O.[Pd]>[NH2:14][C:13]1[CH:12]=[C:11]2[C:7]([C:8]([CH3:24])([CH3:23])[C:9](=[O:22])[N:10]2[CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=[CH:6][C:5]=1[NH:4][CH:1]([CH3:2])[CH3:3]

参加物

4

反応物 1

HCID 674274925-Isopropylamino-3,3-dimethyl-6-nitro-1-pentyl-1,3-dihydro-indol-2-one

生成物 1

HCID 674272526-Amino-5-isopropylamino-3,3-dimethyl-1-pentyl-1,3-dihydro-indol-2-one収率 98.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 6228Dimethylformamide溶媒

実験手順

5-Isopropylamino-3,3-dimethyl-6-nitro-1-pentyl-1,3-dihydro-indol-2-one (200 mg) is dissolved in N,N-dimethylformamide (10 ml) and hydrogenated at RT at 3 bar for 12 h using Pd/C (10%; 0.1 g) as catalyst. After completion of the reaction the mixture is filtered and evaporated to give the compound (180 mg).

後処理

  1. customAfter completion of the reaction the mixture
  2. filtrationis filtered
  3. customevaporated

出典と根拠

ORDレコード
ord-683e9cf6a17f4091985f8279a337732a
出典データセット
uspto-grants-2010_05
特許番号
US07714010B2

反応ノート

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