2-Morpholin-4-yl-7-nitro-1,3-benzothiazole → 2-Morpholin-4-yl-1,3-benzothiazol-7-amine

HRID 2235495ノート

反応式

HRID 2235495 の反応式
[N:1]1([C:7]2[S:8][C:9]3[C:15]([N+:16]([O-])=O)=[CH:14][CH:13]=[CH:12][C:10]=3[N:11]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1>O1CCCC1.[Ni]>[N:1]1([C:7]2[S:8][C:9]3[C:15]([NH2:16])=[CH:14][CH:13]=[CH:12][C:10]=3[N:11]=2)[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

参加物

4

反応物 1

HCID 685822692-Morpholin-4-yl-7-nitro-1,3-benzothiazole

生成物 1

HCID 685811022-Morpholin-4-yl-1,3-benzothiazol-7-amine収率 33.4%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 8028Tetrahydrofuran溶媒

実験手順

To 0.075 g (0.28 mmol) of 2-morpholin-4-yl-7-nitro-1,3-benzothiazole in 6 mL of tetrahydrofuran (THF) was added a pipet tip of Raney nickel. The reaction was kept under a hydrogen atmosphere via a balloon and stirred at room temperature for 5 h. The catalyst was removed via filtration and the filtrate was concentrated in vacuo. Purification by flash chromatography failed to provide clean B so the 0.022 g (33%) of material thus isolated was used without further purification.

後処理

  1. customThe catalyst was removed via filtration
  2. concentrationthe filtrate was concentrated in vacuo
  3. customPurification by flash chromatography

出典と根拠

ORDレコード
ord-e473b00148bf452999d211fc4779340e
出典データセット
uspto-grants-2010_05
特許番号
US07714009B2

反応ノート

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