Thionyl Chloride → 1-tert-Butyl-4-(chloromethyl)-2-isopropylbenzene
反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11]O)=[CH:7][C:6]=1[CH:13]([CH3:15])[CH3:14])([CH3:4])([CH3:3])[CH3:2].S(Cl)([Cl:18])=O>C(Cl)Cl>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][Cl:18])=[CH:7][C:6]=1[CH:13]([CH3:15])[CH3:14])([CH3:4])([CH3:3])[CH3:2]参加物
4
実験手順
Alcohol 26.4 (77.0 mg, 0.37 mmol) was dissolved in anhydrous DCM (5.0 mL). Thionyl chloride (0.041 mL, 0.56 mmol) was added dropwise to the above solution. The resulting mixture was stirred at room temperature for 24 hours. The organic solvent was then removed under vacuo to give a white solid (80 mg). The crude product (26.5) was used in the next step without further purification.
後処理
- customThe organic solvent was then removed under vacuo
出典と根拠
- ORDレコード
- ord-3f1c6d6765af41b2aad8977579550242
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07714008B2
反応ノート
読み込み中…