Triethylamine → 2-(Chloromethyl)-3-methyl-5-[4-(trifluoromethyl)phenyl]thiophene

HRID 2235655ノート

反応式

HRID 2235655 の反応式
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]([CH2:14]O)=[C:11]([CH3:16])[CH:10]=2)=[CH:5][CH:4]=1.C(N(CC)CC)C.S(Cl)([Cl:28])=O>C(Cl)Cl>[Cl:28][CH2:14][C:12]1[S:13][C:9]([C:6]2[CH:7]=[CH:8][C:3]([C:2]([F:18])([F:17])[F:1])=[CH:4][CH:5]=2)=[CH:10][C:11]=1[CH3:16]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 21986444[3-Methyl-5-(4-trifluoromethylphenyl)thien-2-yl]methanol

生成物 1

HCID 159462812-(Chloromethyl)-3-methyl-5-[4-(trifluoromethyl)phenyl]thiophene

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 62.6 (63 mg, 0.23 mmol) in DCM (2.3 mL) were added triethylamine (32 μL, 0.23 mmol) and thionyl chloride (25 μL, 0.35 mmol) at room temperature. The mixture was stirred overnight and concentrated to afford 62.7. The crude product was used without further purification.

後処理

  1. concentrationconcentrated

出典と根拠

ORDレコード
ord-9f7b1846c959464b92b04f8021d2c76a
出典データセット
uspto-grants-2010_05
特許番号
US07714008B2

反応ノート

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