Hydrochloric Acid → 3-[(2,2-Dimethylpropanoyl)amino]propanoic acid
反応式
Cl.[NH2:2][CH2:3][CH2:4][C:5]([O:7]C)=[O:6].[C:9](Cl)(=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11].Cl>[OH-].[Na+]>[CH3:11][C:10]([CH3:13])([CH3:12])[C:9]([NH:2][CH2:3][CH2:4][C:5]([OH:7])=[O:6])=[O:14]参加物
5
実験手順
558 mg (4.03 mmol) of methyl 3-aminopropionate hydrochloride was dissolved in 20 ml of 1 N aqueous sodium hydroxide solution. 362 mg (3.00 mmol) of pivaloyl chloride was immediately added to the obtained solution, and they were stirred for 4 hours. 15 ml of 2 N aqueous hydrochloric acid solution was added to the reaction mixture. After extracting with ethyl acetate 3 times followed by drying under anhydrous sodium sulfate, the solvent was evaporated under reduced pressure to obtain the title compound.
後処理
- extractionAfter extracting with ethyl acetate 3 times
- customby drying under anhydrous sodium sulfate
- customthe solvent was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-363b6d23bf564406afee79a79511d753
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07713957B2
反応ノート
読み込み中…