Acetic Acid → 2-(4-Methylpiperazin-1-yl)pyrimidin-5-amine
反応式
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[N:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][N:9]=2)[CH2:4][CH2:3]1.C(O)(=O)C>CO.[Fe]>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([C:8]2[N:9]=[CH:10][C:11]([NH2:14])=[CH:12][N:13]=2)[CH2:6][CH2:7]1参加物
5
実験手順
A mixture of 2-(4-methyl-piperazin-1-yl)-5-nitro-pyrimidine (446 mg, 2 mmol), iron powder (432 mg, 7.6 mmol), acetic acid (0.884 mL, 14 mmol) in methanol (8 mL) is heated at 65 C for 2 h. It is worked up as before to yield 302 mg (78%) of the title compound. MS (ESI) m/z 194 (M+H)+1.
後処理
- temperatureis heated at 65 C for 2 h
出典と根拠
- ORDレコード
- ord-0cc379c496e449888e8d2cc4d44eb56d
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07713994B2
反応ノート
読み込み中…