Sodium Azide → 2-Azidomethyl-5-propoxy-pyridin-4-ol

HRID 2236539ノート

反応式

HRID 2236539 の反応式
[N-:1]=[N+:2]=[N-:3].[Na+].Cl[CH2:6][C:7]1[CH:12]=[C:11]([OH:13])[C:10]([O:14][CH2:15][CH2:16][CH3:17])=[CH:9][N:8]=1>CN(C)C=O>[N:1]([CH2:6][C:7]1[CH:12]=[C:11]([OH:13])[C:10]([O:14][CH2:15][CH2:16][CH3:17])=[CH:9][N:8]=1)=[N+:2]=[N-:3]

参加物

4

反応物 2

HCID 33557Sodium AzideHCID 178458779HCID 178458779、化合物

生成物 1

HCID 1784587892-Azidomethyl-5-propoxy-pyridin-4-ol

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a suspension of sodium azide (2.82 g, 43.3 mmole) in 30 mL of N,N-dimethylformamide is added 2-chloromethyl-5-propoxy-pyridin-4-ol (8.74 g, 43.3 mmole). This is stirred for overnight at ambient temperature then quenched into ice water. The solid formed is filtered, washed with cold water and dried to give an off white solid, 5.74 g, (63%); MS (ES+): m/z 209.3 (M+H).

後処理

  1. customthen quenched into ice water
  2. customThe solid formed
  3. filtrationis filtered
  4. washwashed with cold water
  5. customdried
  6. customto give an off white solid, 5.74 g, (63%)

出典と根拠

ORDレコード
ord-67ed3b4eb1544676b1725ced3ff6a336
出典データセット
uspto-grants-2010_05
特許番号
US07713994B2

反応ノート

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