2-Methoxy-5-[(methylamino)methyl]phenol → (4Z)-6-bromo-4-{[(3-hydroxy-4-methoxybenzyl)(methyl)amino]methylene}isoquinoline-1,3(2H,4H)-dione

HRID 2236639ノート

反応式

HRID 2236639 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])/[C:5]/2=[CH:14]/OC.[CH3:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][NH:26][CH3:27])=[CH:21][C:20]=1[OH:28]>O1CCCC1>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][C:6](=[O:13])/[C:5]/2=[CH:14]\[N:26]([CH2:25][C:22]1[CH:23]=[CH:24][C:19]([O:18][CH3:17])=[C:20]([OH:28])[CH:21]=1)[CH3:27]

参加物

4

反応物 2

HCID 15199372-Methoxy-5-[(methylamino)methyl]phenolHCID 68692760(E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione

生成物 1

HCID 42625518(4Z)-6-bromo-4-{[(3-hydroxy-4-methoxybenzyl)(methyl)amino]methylene}isoquinoline-1,3(2H,4H)-dione収率 95%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

(4E)-6-Bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione (0.15 g, 0.53 mmol) and 2-methoxy-5-methylaminomethyl-phenol (80 mg, 0.48 mmol) were stirred in tetrahydrofuran (10 mL) at room temperature. The reaction mixture is concentrated under reduced pressure. The solid material is then collected, washed with diethyl ether, water, and methanol, and then dried under vacuum to give (4Z)-6-bromo-4-{[(3-hydroxy-4-methoxybenzyl)(methyl)amino]methylene}isoquinoline-1,3(2H,4H)-dione as a yellow solid (0.19 g, 95%).

後処理

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. customThe solid material is then collected
  3. washwashed with diethyl ether, water, and methanol
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-a0d916b536804624a7cca8fce0f46ee8
出典データセット
uspto-grants-2010_05
特許番号
US07713994B2

反応ノート

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