Hydrochloric Acid → 3-Fluoro-4-MethoxybenzylaMineHCl

HRID 2236657ノート

反応式

HRID 2236657 の反応式
CO[N:3]=[CH:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([F:13])[CH:6]=1.[ClH:14]>C(O)C.[Pd]>[ClH:14].[F:13][C:7]1[CH:6]=[C:5]([CH:10]=[CH:9][C:8]=1[O:11][CH3:12])[CH2:4][NH2:3]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 87542948HCID 87542948、化合物

生成物 1

HCID 224674033-Fluoro-4-MethoxybenzylaMineHCl

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of 3-fluoro-4-methoxy-benzaldehyde O-methyl-oxime (0.60 g, 3.3 mmol) in ethanol (25 mL) is added concentrated ethanolic hydrogen chloride (2 mL) and palladium on carbon (10%, 250 mg). The suspension is hydrogenated at atmospheric pressure for 18 hours, then filtered through diatomaceous earth and finally concentrated to give 3-fluoro-4-methoxy-benzylamine hydrochloride as a white solid.

後処理

  1. filtrationfiltered through diatomaceous earth
  2. concentrationfinally concentrated

出典と根拠

ORDレコード
ord-4749d880f44b4308984218dbc2650049
出典データセット
uspto-grants-2010_05
特許番号
US07713994B2

反応ノート

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