Methyl iodide → 4-(Methoxycarbonyl)-1-methylpyridin-1-ium iodide
反応式
[C:1]([O:9][CH3:10])(=[O:8])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[I:11][CH3:12]>C1C=CC=CC=1>[I-:11].[CH3:10][O:9][C:1]([C:2]1[CH:7]=[CH:6][N+:5]([CH3:12])=[CH:4][CH:3]=1)=[O:8]参加物
4
反応条件
- 温度
- 110 °C
実験手順
To a solution of methyl isonicotinate (5.0 g, 36 mmol) in benzene (165 mL) is added iodomethane (4.5 mL, 72 mmol). The mixture is heated in a 110° C. oil bath for two hours and then allowed to cool to room temperature. The solid is collected by Büchner filtration, washed with hexanes and diethyl ether, and dried under house vacuum to give 4-methoxycarbonyl-1-methylpyridinium iodide (4.6 g, 46%).
後処理
- temperatureto cool to room temperature
- filtrationThe solid is collected by Büchner filtration
- washwashed with hexanes and diethyl ether
- customdried under house vacuum
出典と根拠
- ORDレコード
- ord-e2cfd27a3cc549d4a7098ed6ac9adefa
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07713994B2
反応ノート
読み込み中…