N,N-Dimethylglycine → HCID 178483933、化合物

HRID 2236890ノート

反応式

HRID 2236890 の反応式
[NH2:1][C:2]1[CH:23]=[CH:22][C:5]([CH2:6][NH:7][CH:8]=[C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([I:19])[CH:17]=3)[C:12](=[O:20])[NH:11][C:10]2=[O:21])=[CH:4][C:3]=1[OH:24].C(N(CC)CC)C.[CH3:32][N:33]([CH2:35][C:36](O)=[O:37])[CH3:34].Cl.CN(C)CCCN=C=NCC.ON1C2C=CC=CC=2N=N1>CN(C)C=O>[OH:24][C:3]1[CH:4]=[C:5]([CH2:6][NH:7]/[CH:8]=[C:9]2\[C:10](=[O:21])[NH:11][C:12](=[O:20])[C:13]3[C:18]\2=[CH:17][C:16]([I:19])=[CH:15][CH:14]=3)[CH:22]=[CH:23][C:2]=1[NH:1][C:36](=[O:37])[CH2:35][N:33]([CH3:34])[CH3:32]

参加物

7

反応物 5

HCID 673N,N-DimethylglycineHCID 8471TriethylamineHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 178507623HCID 178507623、化合物

生成物 1

HCID 178483933HCID 178483933、化合物収率 20.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

4-[(4-Amino-3-hydroxy-benzylamino)-methylene]-6-iodo-4H-isoquinoline-1,3-dione (89 mg, 0.20 mmol) is dissolved in N,N-dimethylformamide (3.56 mL), followed by addition of triethylamine (0.236 mL, 1.69 mmol), dimethylamino-acetic acid (30.58 mg, 0.30 mmol), 1-[3-(dimethylamino)propyl]-3-ethylcarbodimide hydrochloride (42.6 mg, 0.22 mmol) and 1-hydroxybenzotriazole (13.8 mg, 0.10 mmol). It is stirred at room temperature overnight. It is then evaporated to dryness, and the residue is washed with ether, and then acetonitrile to yield 21 mg (20%) of the title compound as a solid. MS (ESI) m/z 521 (M+H)+1

後処理

  1. customIt is then evaporated to dryness
  2. washthe residue is washed with ether

出典と根拠

ORDレコード
ord-a3602823b1b84b189395e222440501be
出典データセット
uspto-grants-2010_05
特許番号
US07713994B2

反応ノート

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