反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[O:10])[C:7]([OH:9])=[O:8].[CH3:11][CH2:12]O.OS(O)(=O)=O>C(Cl)(Cl)Cl>[CH2:11]([O:8][C:7](=[O:9])[C:6]([C:2]1[O:1][CH:5]=[CH:4][CH:3]=1)=[O:10])[CH3:12]参加物
5
反応条件
- 温度
- 63 °C
実験手順
Furan-2-yl-oxo-acetic acid (15 g, 107 mmol), dissolved in CHCl3 (420 ml), was treated with EtOH (9.6 ml, 165 mmol) and H2SO4 (1 ml) and heated to 63° C. for 12 hours. Next, the reaction mixture was transferred to a separatory funnel and washed with sat. NaHCO3 (100 ml). The organic layer was washed with brine (100 ml), dried (MgSO4) and concentrated providing 16.9 g (66%) of the above subtitle compound, which was carried forward without further purification.
後処理
- customNext, the reaction mixture was transferred to a separatory funnel
- washwashed with sat. NaHCO3 (100 ml)
- washThe organic layer was washed with brine (100 ml)
- dry with materialdried (MgSO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-9e491eb9b6714739bd53595f46e49a6d
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07718647B2
関連ノート
読み込み中…