反応式
C([O:3][C:4](=[O:12])[C:5]([C:7]1[O:8][CH:9]=[CH:10][CH:11]=1)=[O:6])C.[BH4-].[Na+]>CCO.O>[O:8]1[CH:9]=[CH:10][CH:11]=[C:7]1[CH:5]([OH:6])[C:4]([OH:12])=[O:3]参加物
5
実験手順
A solution of the product from step a.) (25 g, 135 mmol) in EtOH (250 ml) was cooled to 0° C. and treated with a solution of NaBH4 (2.5 g, 66 mmol) in H2O (27 ml) for 5 minutes. Next, the reaction mixture was quenched with AcOH (17 ml) and H2O (271 ml) and concentrated to dryness. The crude oil was dissolved in CH2Cl2 (300 ml), washed with brine (2×100 ml), dried (MgSO4) and concentrated providing 17.5 g (70%) of the above subtitle compound, which was carried forward without further purification.
後処理
- customNext, the reaction mixture was quenched with AcOH (17 ml) and H2O (271 ml)
- concentrationconcentrated to dryness
- dissolutionThe crude oil was dissolved in CH2Cl2 (300 ml)
- washwashed with brine (2×100 ml)
- dry with materialdried (MgSO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-8be1c5878a6f405eb4d8bbf1b8bbe68a
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07718647B2
関連ノート
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