Hydrochloric Acid → 861451-21-0
反応式
[CH3:1][C:2]([C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)([CH3:7])[C:3]([O:5][CH3:6])=[O:4].[ClH:14]>CO.[Pt](=O)=O>[ClH:14].[CH3:7][C:2]([CH:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)([CH3:1])[C:3]([O:5][CH3:6])=[O:4]参加物
5
実験手順
0.115 g of methyl 2-methyl-2-pyridin-4-ylpropionate (CAS 79757-27-0) is dissolved in an autoclave in 5 ml of methanol. The solution is admixed with 0.35 ml of 1.2M HCl in methanol and 0.012 g of platinum(IV) oxide, and the reaction mixture is hydrogenated at 4 bar and 23° over 46 hours. The catalyst is filtered off through Hyflo and the filtrate is concentrated by evaporation. The title compound is obtained as a light brown solid. Rf0.05 (200:20:1 dichloromethane-methanol-25% conc. ammonia).
後処理
- filtrationThe catalyst is filtered off through Hyflo
- concentrationthe filtrate is concentrated by evaporation
出典と根拠
- ORDレコード
- ord-ef7adeadee3145f2924020768b8244c3
- 出典データセット
- uspto-grants-2010_05
- 特許番号
- US07718675B2
反応ノート
読み込み中…