Hydrochloric Acid → Fasudil

HRID 2238452

反応式

HRID 2238452 の反応式
[CH:1]1[CH:2]=[C:3]2[C:8](=[C:9]([S:11]([N:14]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16][CH2:15]3)(=[O:13])=[O:12])[CH:10]=1)[CH:7]=[CH:6][N:5]=[CH:4]2.Cl.[Cl-].[Na+].Cl.[OH-].[Na+]>O>[CH:1]1[CH:2]=[C:3]2[C:8](=[C:9]([S:11]([N:14]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16][CH2:15]3)(=[O:13])=[O:12])[CH:10]=1)[CH:7]=[CH:6][N:5]=[CH:4]2

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 14798Sodium HydroxideHCID 163751Fasudil Hydrochloride

生成物 1

HCID 3547Fasudil

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

Fasudil-hydrochloride ½ hydrate (3.08 g) and sodium chloride (0.8 g, manufactured by Wako Pure Chemical Industries, Ltd.) were dissolved in water (80 ml). After adjusting the pH of all solutions to 1, 2, 3, 4, 5, 6, 7, 7.5, 8, and 9 by addition of a diluted hydrochloric acid or sodium hydroxide reagent solution, the volume of each solution was adjusted to 100 ml by addition of water. The fasudil hydrochloride aqueous solutions were aseptically filtered and 2 ml of the filtrates were filled in transparent and colorless glass ampoules (2 ml (manufactured by Namicos Corp.)). The ampoules were melt-sealed to obtain fasudil-containing preparations with the pH of 1-9 (hereinafter referred to as “fasudil hydrochloride-containing preparations”).

後処理

  1. filtrationThe fasudil hydrochloride aqueous solutions were aseptically filtered
  2. addition2 ml of the filtrates were filled in transparent and colorless glass ampoules (2 ml (manufactured by Namicos Corp.))
  3. customThe ampoules were melt-sealed

出典と根拠

ORDレコード
ord-0caff890e69044238c002ca53048d100
出典データセット
uspto-grants-2010_05
特許番号
US07718797B2

関連ノート

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