Sulfuric Acid → 3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one sulfate
反応式
[S:1](=[O:5])(=[O:4])([OH:3])[OH:2].[C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]1[C:15](=[O:32])[N:16]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:17]=[C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=2)[CH:19]=1)#[N:7]>O1CCCC1>[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]1[C:15](=[O:32])[N:16]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:17]=[C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=2)[CH:19]=1)#[N:7]参加物
4
実験手順
A mixture of concentrated sulfuric acid (60 μL, 1.08 mmol) and tetrahydrofuran (5 mL) was added under cooling with ice to a mixture of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one (200 mg, 0.138 mmol) and tetrahydrofuran (20 mL), which was then stirred under cooling with ice for one hour. The precipitated solid was collected by filtration, washed with ethyl acetate (small amount), and then dried under reduced pressure to provide 212 mg of the title compound as white crystals.