N-bromobutanimide → 3-bromo-5H,6H,7H,8H-imidazo[1,2-a]pyridine

HRID 2238643ノート

反応式

HRID 2238643 の反応式
[N:1]1[CH:2]=[CH:3][N:4]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=12.[Br:10]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Br:10][C:3]1[N:4]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]2=[N:1][CH:2]=1

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 99892645H,6H,7H,8H-imidazo[1,2-a]pyridine

生成物 1

HCID 100356983-bromo-5H,6H,7H,8H-imidazo[1,2-a]pyridine収率 25.1%

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

375 mg of the 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine [44-1] was dissolved in 10 mL of carbon tetrachloride, then 546 mg of N-bromosuccinimide was added, and the mixture was heated for 30 minutes under reflux. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography and then by preparative thin-layer chromatography sequentially, to obtain 155 mg of 3-bromo-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine [44-2] as a pale yellow solid.

後処理

  1. temperaturethe mixture was heated for 30 minutes
  2. temperatureunder reflux
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. customthe residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-7fb63aabd4374955aa2831c51f16155d
出典データセット
uspto-grants-2010_05
特許番号
US07718801B2

反応ノート

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