Trifluoroacetic acid → HCID 68707478、化合物
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:40][C:12]3[C:13](=[O:39])[N:14]([CH2:17][C:18]4[N:23]=[C:22]([O:24][CH2:25][C@@H:26]5[CH2:31][CH2:30][CH2:29][CH2:28][N:27]5C(OC(C)(C)C)=O)[CH:21]=[CH:20][CH:19]=4)[N:15]=[CH:16][C:11]=3[CH:10]=2)=[CH:5][CH:4]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[S:40][C:12]3[C:13](=[O:39])[N:14]([CH2:17][C:18]4[CH:19]=[CH:20][CH:21]=[C:22]([O:24][CH2:25][C@@H:26]5[CH2:31][CH2:30][CH2:29][CH2:28][NH:27]5)[N:23]=4)[N:15]=[CH:16][C:11]=3[CH:10]=2)=[CH:7][CH:8]=1参加物
4
実験手順
tert-Butyl (2S)-2-{[(6-{[2-(4-methoxyphenyl)-7-oxothieno[2,3-d]pyridazin-6(7H)-yl]methyl}pyridin-2-yl)oxy]methyl}piperidine-1-carboxylate (354 mg, 0.629 mmol) was dissolved in DCM (7 ml) and TFA (1 ml) was added. The reaction was stirred at rt. for 30 min and the solvent evaporated in vacuo. To the resultant oil was added DCM (100 ml) and 5% Na2CO3 (aq) (100 ml), the phases separated and the aqueous phase extracted with DCM (100 ml). The combined organics were dried through a phase separator and evaporated in vacuo yielding the title compound as a light yellow solid. Yield: 290 mg (100%). MS (ESI+) 463.23 (M+1H+)