Potassium Carbonate → 2-{2-[(2-Isopropyl-1,1-dioxido-3-oxo-5-phenyl-2,3-dihydroisothiazol-4-yl)amino]ethoxy}phenyl methanesulfonate

HRID 2239717ノート

反応式

HRID 2239717 の反応式
CC1C=CC(S(O[CH2:12][CH2:13][NH:14][C:15]2[C:16](=[O:31])[N:17]([CH:28]([CH3:30])[CH3:29])[S:18](=[O:27])(=[O:26])[C:19]=2[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)(=O)=O)=CC=1.[CH3:32][S:33]([O:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=1[OH:43])(=[O:35])=[O:34].C(=O)([O-])[O-].[K+].[K+]>CC#N>[CH3:32][S:33]([O:36][C:37]1[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=1[O:43][CH2:12][CH2:13][NH:14][C:15]1[C:16](=[O:31])[N:17]([CH:28]([CH3:29])[CH3:30])[S:18](=[O:26])(=[O:27])[C:19]=1[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1)(=[O:35])=[O:34]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 132483392-Hydroxyphenyl methanesulfonateHCID 866258832-[(2-Isopropyl-1,1-dioxido-3-oxo-5-phenyl-2,3-dihydroisothiazol-4-yl)amino]ethyl 4-methylbenzenesulfonate

生成物 1

HCID 866258822-{2-[(2-Isopropyl-1,1-dioxido-3-oxo-5-phenyl-2,3-dihydroisothiazol-4-yl)amino]ethoxy}phenyl methanesulfonate収率 15%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
120 °C

実験手順

2-[(2-Isopropyl-1,1-dioxido-3-oxo-5-phenyl-2,3-dihydroisothiazol-4-yl)amino]ethyl 4-methylbenzenesulfonate (200 mg, 0.431 mmol) was dissolved in dry MeCN (4 mL) under nitrogen atmosphere. 2-Hydroxyphenyl methanesulfonate (89 mg, 0.474 mmol) was added followed by potassium carbonate (297 mg, 2.152 mmol). The reaction mixture was heated in a microwave reactor for 15 mins at 120° C. Potassium carbonate was filtered off and the reaction mixture was concentrated and redissolved in EtOAc. The mixture was washed with NaHCO3, dried over Na2SO4, filtered and evaporated. The residue was purified on a Horizon TM flash system using Heptane and EtOAc as eluant and TEA as additative and then purified by column chromatography (ISOLUTE SI, (5 g)) using DCM as eluant to afford the title compound (31 mg, 15%). 1H NMR (CDCl3, 500 MHz): δ 1.59 (d, 6H), 3.22 (s, 3H), 3.31 (q, 2H), 3.96 (t, 2H), 4.38-4.46 (m, 1H), 5.88 (t, 1H), 6.89 (d, 1H), 7.02 (t, 1H), 7.23-7.30 (m, 2H), 7.46-7.48 (m, 3H), 7.53-7.56 (m, 2H); 13C NMR (CDCl3, 125 MHz): δ 20.38, 38.57, 43.36, 47.85, 67.23, 108.08, 114.71, 122.38, 124.59, 125.14, 128.55, 129.15, 130.09, 131.63, 135.62, 138.64, 150.55, 158.40; Mass Spectrum: M+H+ 481.1.

後処理

  1. filtrationPotassium carbonate was filtered off
  2. concentrationthe reaction mixture was concentrated
  3. dissolutionredissolved in EtOAc
  4. washThe mixture was washed with NaHCO3
  5. dry with materialdried over Na2SO4
  6. filtrationfiltered
  7. customevaporated
  8. customThe residue was purified on a Horizon TM flash system
  9. customTEA as additative and then purified by column chromatography (ISOLUTE SI, (5 g))

出典と根拠

ORDレコード
ord-8b09fb9b258046dd91dbbb5fc2c4960b
出典データセット
uspto-grants-2010_05
特許番号
US07723333B2

反応ノート

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